Virginia Tech™home

Kevin Edgar

Professor, Biomaterials and Bioprocessing; Director, ICTAS Bio-Based Materials Center; Ph.D. (Duke)
Headshot of Kevin J. Edgar
Kevin J. Edgar
Sustainable Biomaterials
230 Cheatham Hall (0323)
Blacksburg, VA
24061

Dr. Edgar's lab designs and creates derivatives of natural polysaccharides to address demanding performance requirements. They explore the structure-property-performance relationships of these materials, for diverse and demanding applications including drug-delivery systems, tissue engineering, biodegradable plastics, polymer compatibilization, hydrogels, and block copolymers. He is interested in novel methods to control and utilize the nanostructure of polysaccharides and derivatives, in particular the regioselective substitution reactions of complex polysaccharides, as well as the preparation of polysaccharides with controlled sequences.

His research more broadly addresses more effective ways of utilizing the vast abundance and diversity of natural polysaccharides to address societal needs. These sustainable, generally benign materials have an enormous variety of natural functions, ranging from structural, to rheology modification, to energy storage, to information storage and communication (glycosaminoglycans for example have the highest density of information storage of any natural polymer family, vastly greater than that of proteins and polynucleic acids like DNA and RNA). They have enormous potential for meeting challenging application demands while reducing the need for fossil fuel-based materials.

Edgar is active in the Macromolecules and Interfaces Institute (MII) and in the Institute for Critical Technologies and Applied Science (ICTAS). He is a member of the NSF sponsored Materials Innovation Platform focusing on glycoscience (GlycoMIP), and he is co-Director of the Infectious Disease Interdisciplinary Graduate Education Program (ID IGEP). He leads a track within the ICTAS Center for Engineered Health.

He is an editor-in-chief of the journal Carbohydrate Polymers, and a member of the editorial boards of the journals Biomacromolecules and Cellulose. He is an active member of the American Chemical Society and of its Division of Cellulose and Renewable Materials.

To learn more about Kevin, read this article from our series One of Us.

Area of Expertise

  • Creation of drug delivery systems to meet patient needs
  • Bioavailability enhancement
  • Selective synthesis of novel polysaccharide derivatives
  • Polysaccharide-based hydrogels and block copolymers
  • Polysaccharide chemistry
  • Structure-property-performance relationships 
  • Sustainable-based materials for demanding applications

Education

  • B.S. Chemistry, Bucknell University, 1975
  • Ph.D. Organic Chemistry, Duke University, 1979

Polysaccharide Chemistry – Conjoint and crosslisted class (Advanced Polysaccharide Chemistry, SBIO 5424G and CHEM 5424G; Polysaccharide Chemistry, SBIO 4424 and CHEM 4424)

GTA Workshop – GRAD 5004

 

 

“Regioselective Synthesis of Novel Cellulose Derivatives for Drug Delivery”, S. Carter Fox, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, Nov. 4, 2011.

“Regioselective synthesis of cellulose derivatives”, Daiqiang Xu, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2012.

“Chemical modification of alginates in organic media”, Siddhesh Pawar, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Synthesis of new pullulan derivatives for drug delivery, Junia M. Pereira, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery”, Haoyu Liu, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Regioselective Synthesis of Cellulose Esters”, Xueyan Zheng, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2014.

“Pullulan w-carboxyalkanoates for drug nanodispersions”, Jameison Rolle, Submitted in partial fulfillment of requirements for Masters of Science in Macromolecular Science and Engineering, 2015.

“Synthesis and applications of cellulose derivatives for drug delivery”, Joyann Marks, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2015.

“Regioselective synthesis of curdlan derivatives”, Ruoran Zhang, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2015.

“Chemical Modification of Cellulose Esters for Oral Drug Delivery”, Xiangtao Meng, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2016.

“Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems”, H. Cigdem Arca, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2016.

“Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery”, Yifan Dong, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2017.

“Regioselective Synthesis of Polysaccharide-based Polyelectrolytes”, Shu Liu, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2017.

“Regioselective Chlorination of Cellulose Esters”, Chengzhe Gao, Submitted in partial fulfillment of requirements for M.S. in Chemistry, June 2018.

“Regioselective Synthesis of Glycosaminoglycan Analogs”, Chengzhe Gao, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, February 2019.

“Synthesis and Structure-Property Relationships of Polysaccharide-Based Block Copolymers and Hydrogels”, Junyi Chen, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, December 2019.

  • Liebert, T.F.; Heinze, T.J.; Edgar, K.J. 2010. Cellulose Solvents: For Analysis, Shaping and Chemical Modification. Editor, ACS Symposium Series 1033, 2010, ACS, Washington, DC.

  • Edgar, K.J.; Heinze, T.; Buchanan, C.M. 2009. Polysaccharide Materials: Performance by Design. Lead Editor, ACS Symposium Series 1017, ACS, Washington DC, 2009.
  • K.J. Edgar. 2009. Polysaccharide Chemistry: Frontiers and Challenges. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • C.M. Buchanan, N.L. Buchanan, K.J. Edgar, S. Klein, J.L. Little, M.G. Ramsey, K.M. Ruble, V.J. Wacher, M.F. Wempe. 2009. Building New Drug Delivery Systems: in vitro and in vivo studies of drug-hydroxybutenylcyclodextrin complexes. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • J.D. Posey-Dowty, M.C. Shelton, K.J. Edgar. 2009. Novel Cellulose Esters in Amorphous Matrix Drug Delivery. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design. K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • K.J. Edgar. 2009. Synthetic Methods for Long-chain Esters of Cellulose. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.

  • Edgar, Kevin J. 2007. Special Issue of Cellulose on Polysaccharides in Drug Delivery. Guest editorial in the journal Cellulose, Issue 1, Volume 14, 2007, pages 1-2.

Develop a Prototype Formulation for Drug Delivery
Investigator(s): L.S. Taylor, K.J. Edgar
Sponsor: NSF PFI: AIR
Amount: $68,000
August 15, 2013 - August 14, 2014

Collaborative Research: Polysaccharide Derivatives for Drug Delivery
Investigator(s): L.S. Taylor, K.J. Edgar
Sponsor: NSF Biomaterials
Amount: $325,000
January 15, 2013 - January 14, 2016

MRI: Acquisition of a dual size-exclusion chromatography- asymmetric flow field flow fractionation instrument
Investigator(s): J. McGrath, R.M. Davis, J.S. Riffle, S.R. Turner, K.J. Edgar
Sponsor: NSF
Amount: $255,265
August 1, 2011 - July 31, 2014

Aqueous GPC
Investigator(s): Edgar, K.J. (PI); Roman, M.; Renneckar, S.; Frazier, C.E. and 11 others
Sponsor: ICTAS
Amount: $136,000
March 1, 2011 - June 30, 2011

Regiospecific Synthesis of High-value Cellulose Esters and Ethers from Biomass
Investigator(s): Edgar, K.J. (PI); Buchanan, C.M.; Mischnick, P
Sponsor: USDA-NIFA
Amount: $816,049
February 1, 2011 - January 31, 2016

Amorphous Nanoparticles
Investigator(s): Edgar, K.J.; Davis, R.M
Sponsor: VT-CRI
Amount: $30,000
July 1, 2009 - June 30, 2010

SEMRR: Developing Sustainable Bioenergy Feedstocks and Cellulosic Composites
Investigator(s): Audrey Zink-Sharp, Chad Bolding, Carolyn Copenheaver, Kevin Edgar, Thomas R. Fox, Charles Frazier, Scott Renneckar, Maren Roman, and Shepard Zedaker
Sponsor: USDA NIFA Special Grant Program
Amount: $451,374.00
April 1, 2010 - March 31, 2012

Controlled Release of Phytochemicals
Investigator(s): Edgar, K.J.; Vinatzer, B
Sponsor: Fralin Institute
Amount: $15,000
June 1, 2010 - May 31, 2011

Enhanced Delivery of Phytochemicals by Nanodispersion in Polysaccharide Matrices
Investigator(s): K.J. Edgar, L.S. Taylor, L.J. Mauer
Sponsor: USDA
Amount: $405K
January 1, 2009 - December 31, 2011

Education Proposal: Bio-based Sustainable Materials as Resources for Tomorrow (BSMART)
Investigator(s): S. Renneckar, J. Barone, K. Edgar, A. Esker, J. Freeman, A. Morgan, and M. Roman
Sponsor: USDA CSREES
Amount: $500,000
December 1, 2009 - November 30, 2013

SEMRR: Creating Advanced Cellulosic Composites and Biobased Energy Feedstocks
Investigator(s): A.G. Zink-Sharp, K.J. Edgar, et al
Sponsor: USDA
Amount: $458K
September 1, 2009 - August 31, 2010

Cellulose Analysis
Investigator(s): Renneckar, S.H.; Edgar, K.J.; Zink-Sharp, A
Sponsor: US Army
Amount: $80,000
January 1, 2008 - January 31, 2009

SEMRR: Creating Advanced Cellulosic Composites and Biobased Energy Feedstocks
Investigator(s): Audrey Zink-Sharp, Kevin J. Edgar, Thomas Fox, Charles Frazier, Scott Renneckar, Maren Roman, and Shepard Zedaker
Sponsor: USDA CSREES Special Grants Program
Amount: $452,159
October 1, 2009 - September 31, 2011

Bio-Based Materials Center
Investigator(s): K.J. Edgar and 12 others
Sponsor: ICTAS
Amount: $110K
July 1, 2009 - June 30, 2010

Collaborative Research: Polysaccharide Derivatives for Enhanced Drug Delivery
Investigator(s): L. Taylor, K.J. Edgar
Sponsor: NSF
Amount: $404K
September 1, 2008 - August 31, 2011

Bio-based Materials Center at Virginia Tech
Investigator(s): Kevin J. Edgar, Foster Agblevor, Justin Barone, Alan R. Esker, Paul Gatenholm, Sean McGinnis, Abby Morgan, Scott Renneckar, Maren Roman, Zhiyou Wen, Y.-H. Percival Zhang
Sponsor: Virginia Tech Institute for Critical Technology and Applied Science
Amount: $205,303
January 1, 2008 - June 30, 2009

SEMRR:Innovative Forest Management Linked with High Performance, Wood-Based Composites
Investigator(s): Audrey Zink-Sharp, C. Copenheaver, K. Edgar, U. Egertsdotter, T. Fox, C. Frazier, S. Renneckar, M. Roman, and S. Zedaker
Sponsor: USDA CSREES McIntire-Stennis
Amount: $221,732
September 1, 2007 - August 31, 2008

 

  • PFI:RFP Innovation of Materials Based on Sustainable Resources to Enhance Performance of Challenging Drugs and Drug Candidates. Investigators: Kevin J. Edgar (PI), Lynne S. Taylor (Co-PI). Sponsor: NSF. Duration: 2018-2021
  • All-polysaccharide, self-assembling, self-healing nanogels for delivery of crop protection agents. Investigators: Kevin J. Edgar (PI), Charles E. Frazier (Co-PI), Wade Thomason (Co-PI). Sponsor: USDA NIFA. Duration: 2020-2023.
  • GlycoMIP (Materials Innovation Platform). Investigators: Maren Roman (PI), Kevin J. Edgar, et al. Sponsor: NSF. Duration: 2019-2024.
  • 2020 Virginia Tech College of Natural Resources and Environment Research Achievement Award
  • 2020 Student Chengzhe Gao received Graduate School Doctoral Assistantship award in Chemistry
  • 2019 Student Chengzhe Gao received Eastman Fellowship in Polymer Science
  • 2016 Student Yifan Dong received Eastman Award as outstanding graduate student from CELL
  • 2016 Anselme Payen Award for outstanding professional contributions to the science and chemical technology of cellulose and its allied products, from the Cellulose and Renewable Materials Division (CELL) of the American Chemical Society (ACS)
  • 2015 Student Xiangtao Meng received Eastman Award as outstanding graduate student from CELL
  • 2013 Student Haoyu Liu received Eastman Award as the outstanding graduate student from CELL
  • 2012 Student Daiqiang Xu received Eastman Award as the outstanding graduate student from CELL
  • 2010 Named Fellow of the ACS Division of Cellulose and Renewable Materials
  • 2009 Named Fellow of ACS (member of the inaugural class of ACS Fellows)

Recent examples from among 121 total refereed publications (graduate student authors indicated by asterisk*, undergraduate authors indicated by carat^):

Nichols, B.L.B.*; Chen, J.*; Mischnick, P.; Edgar, K.J. Selective oxidation of hydroxypropyl ethers of cellulose and dextran. Simple and efficient introduction of versatile ketone groups to polysaccharide. doi.org/10.1021/acs.biomac.0c01045

Hettegger, H.; Steinkellner, K.; Zwirchmayr, N.S.; Potthast, A.; Edgar, K.J.; Rosenau, T. Reaction of 2,5-dihydroxy-[1,4]-benzoquinone with nucleophiles – ipso-substitution vs. addition/elimination. Chem. Commun. 2020, 56, 12845-12848. DOI: 10.1039/D0CC04748A

Edgar, K.J. and Marks, J.A., 2020. Green Hydrogels Based on Starch: Preparation Methods for Biomedical Applications. In Sustainability & Green Polymer Chemistry Volume 1: Green Products and Processes (pp. 173-196). American Chemical Society.

Wilson, V.; Lou, X.; Osterling, D.; Stolarik, D.; Jenkins, G.; Nichols, B.*; Dong, Y.*; Edgar, K.J.; Zhang, G.; Taylor, L.S. Amorphous Solid Dispersions of Enzalutamide and Novel Polysaccharide Derivatives: Investigation of Relationships between Polymer Structure and Performance. Scientific Reports, 2020, 10(1), pp. 1-12.

Chen, J.*; Nichols, B.L.B.*; Norris, A.M. ; Frazier, C.E.; Edgar, K.J. All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides. Biomacromolecules 2020, 21, 4262-4272.

Zhang, H.-H.; Edgar, K.J. Antibacterial modification of Lyocell fiber: A review. Carbohydr. Polym., 2020, 250, 116932.

Chen, J.*; Spiering, G.; Mosquera-Giraldo, L; Moore, R.B.; Edgar, K.J. Regioselective bromination of the dextran non-reducing end creates a pathway to dextran-based block copolymers. Biomacromolecules 2020, 21, 1729-1738.

Chen, J.*; Kamitakahara, H.; Edgar, K.J. Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis. Carbohydr. Polym. 2020, 229, 115530.

Volokhova, A.; Edgar, K.J.; Matson, J.B. Polysaccharide-containing block copolymers: Synthesis and applications. Materials Chemistry Frontiers 2020, 4, 99-112.

Ho, D.-K.; Nichols, B.*; Edgar, K.J.; Murgia, X.; Loretz, B.; Lehr, C.-M. Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections. Eur. J. Pharm. Biopharm. 2019, 144, 110-124.

Dong, Y.*; Novo, D.C.*; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Conjugation of Bile Esters to Cellulose by Olefin Cross-metathesis: A Strategy for Accessing Complex Polysaccharide Structures. Carbohydr. Polym. 2019, 221, 37-47.

Arrington, K.J.; Haag, J.V.; French, E.V.; Murayama, M.; Edgar, K.J.; Matson, J.B. Toughening cellulose: compatibilizing polybutadiene and cellulose triacetate blends. ACS Macro Letters 2019, 8, 447-453.

Gao, C.*; Fisher, Z.B.^; Edgar, K.J. Azide reduction by DTT or thioacetic acid provides access to amino and amido polysaccharides. Cellulose 2019, 26, 445-462.

Mosquera-Giraldo, L.I.; Borca, C.H.; Parker, A.S.; Dong, Y.*; Edgar, K.J.; Beaudoin, S.P.; Slipchenko, L.V.; Taylor, L.S. Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules 2018, 19, 4593-4606.

Gao, C.*; Edgar, K.J. Efficient Synthesis of Glycosaminoglycan Analogs. Biomacromolecules, 2019, 20, 608-617.

Arca, H.C.*; Mosquera-Giraldo, L.I.; Bi, V.; Xu, D.*; Taylor, L.S.; Edgar, K.J. Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules 2018, 19, 2351-2376.

Gao, C.*; Liu, S.*; Edgar, K.J. Regioselective chlorination of cellulose esters by methanesulfonyl chloride. Carbohydr. Polym. 2018, 193, 108-118.

Mosquera-Giraldo, L.I.; Li, N.; Wilson, V.; Nichols, B.L.B.*; Edgar, K.J.; Taylor, L.S. Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Mol. Pharm. 2018, 15, 1700-1713.

Liu, S.*; Gao, C.*; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Selective Synthesis of Curdlan w-Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydr. Polym., 2018, 190, 222-231.

Winslow, C.; Nichols, B.L.B.*; Novo, D.*; Mosquera-Giraldo; L.I.; Taylor, L.S.; Edgar, K.J.; Neilson, A.P. Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydr. Polym., 2018, 182, 149-158.

Arca, H.C.*; Mosquera-Giraldo, L.I.; Dahal, D.^; Taylor, L.S.; Edgar, K.J. Multidrug, anti-HIV amorphous solid dispersions: nature and mechanisms of impacts of drugs on each other’s solution concentrations. Mol. Pharm. 2017, 14, 3617-3627.

Arca, H.C.*; Mosquera-Giraldo, L.I.; Pereira, J.M.*; Sriranganathan, N.; Taylor, L.S.; Edgar, K.J. Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose w-Carboxyalkanoate Matrices. J. Pharm. Sci. 2018, 107, 127-138.

Dong, Y.*; Matson, J.B.; Edgar, K.J., Olefin Cross-Metathesis in Polymer and Polysaccharide Chemistry: A Review. Biomacromolecules 2017, 18, 1661-1676.

Zhang, R.*; Liu, S.*; Edgar, K.J. Efficient Synthesis of Secondary Amines by Reductive Amination of Curdlan Staudinger Ylides. Carbohydr. Polym. 2017, 171, 1-8.

Dong, Y.*; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polym. Chem., 2017, 8, 3129-3139.

Liu, S.; Edgar, K.J. Water-Soluble Co-polyelectrolytes by Selective Modification of Cellulose Esters, Carbohydrate Polymers, 2017, 162, 1-9.

Mosquera-Giraldo, L.I.; Borca, C.H.; Meng, X.*; Edgar, K.J.; Slipchenko, L.V.; Taylor, L.S. Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug Delivery. Biomacromolecules, 2016, 17, 3659-3671.

Gilley, A.D.; Arca, H.C.*; Nichols, B.L.B.*; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J.; Neilson, A.P. Novel Cellulose-Based Amorphous Solid Dispersions Enhance Quercetin Solution Concentrations In Vitro. Carbohydrate Polymers, 2017, 157, 86-93.

Dong, Y.*; Mosquera-Giraldo, L.I.; Troutman, J.^; Skogstad, B.^; Taylor, L.S.; Edgar, K.J. Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polym. Chem., 2016, 7, 4953-4963.

Meng, X.*; Choudhury, S.R.; Edgar, K.J. Multifunctional cellulose esters by olefin cross-metathesis and thiol-Michael addition. Polym. Chem. 2016, 7, 3848-3856.

  • “Polysaccharide derivatives and cross-metathesis processes for preparing them”, Edgar, K.J.; Meng, X. U.S. Patent allowed, August 2020.
  • “Cross-metathesized polysaccharide derivatives and processes for preparing them”, Edgar, K.J.; Meng, X.; Matson, J.B. U.S. Patent 10,738,134 (2020).
  • “Regioselectively Substituted Cellulose Esters And Efficient Methods Of Preparing Them”, Edgar, K.J.; Xu, D.; Zheng, X. U.S. Patent 9,624,311 (2017).
  • “Esters Of Cellulosic Materials And Diacids And Method Of Making Thereof”, U.S. Patent 9,708,415 (2017).
  • “Carbohydrate Esters and Polyol Esters as Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. U.S. 7,276,546 (2007).
  • “Carbohydrate Esters and Polyol Esters as Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. U.S. 6,977,275 (2005).
  • “Novel Carbohydrate Esters and Polyol Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. US 6,977,275 (2005).
  • “Process for Preparing Cellulose Esters Using a Sulfonic Acid Catalyst”, Edgar, K.J., US 6,160,111 (2000).
  • “Process for the Co-production of Dissolving Grade Pulp and Xylan”, Hyatt, J.A.; Fengl, R.W.; Edgar, K.J.; Alvarez-Wright, M.T., US 6,057,438 (2000).
  • “Direct Process for the Production of Cellulose Esters”, Edgar, K.J.; Bogan, R.T., US 5,929,229 (1999).
  • “Process for Preparing Cellulose Acetoacetate Alkanoates”, Kuo, C.M.; Edgar, K.J., US 5,770,726 (1998).
  • “Direct Process for the Production of Cellulose Esters”, Edgar, K.J.; Bogan, R.T., US 5,750,677 (1998).
  • “Process for Preparing Cellulose Esters by Use of Carboxylic Acids”, Edgar, K.J.; Buchanan, C.M. U.S. 5,597,912 (1997).
  • “Cellulose Acetoacetate Esters Used in Coating Compositions”, Edgar, K.J.; Lawniczak, J.E. US 5,595,591 (1997).
  • “Cellulose Acetoacetate Esters”, Edgar, K.J.; Lawniczak, J.E. U.S. 5,521,304 (1996).
  • “Cellulose Acetoacetate Esters”, Edgar, K.J.; Lawniczak, J.E. U.S. 5,420,267 (1995).
  • “Cellulose Acetoacetates”, Edgar, K.J.; Blount, Jr., W.W. U.S. 5,360,843 (1994).
  • “Miscible Blends of Cellulose Esters and Vinylphenol Containing Polymers”, Landry, C.J.T.; Teegarden, D.M.; Edgar, K.J.; Kelley, S.S. U.S. 5,302,637 (1994).
  • “Cellulose Acetoacetates”, Edgar, K.J.; Blount, Jr., W.W. U.S. 5,292,877 (1994).
  • “Cellulose Ester Compositions and Process for the Preparation Thereof”, Bellas, M.; Buchanan, C.M.; Edgar, K.J.; Germroth, T.C.; Wilson, A.W. U.S. 5,142,034 (1992).
  • “Process for the Iodination of Hydroxyaromatic and Aminoaromatic Compounds”, Edgar, K.J.; Steinmetz, G.R. U.S. 4,997,946 (1991).
  • “Preparation of 4-Substituted Aryl Olefins”, Edgar, K.J. U.S. 4,965,361 (1990).
  • “Process for the Carbonylation of Iodoaromatic Compounds”, Steinmetz, G.R.; Edgar, K.J.; Falling, S.N. U.S. 4, 885,384 (1989).
  • “Preparation of 2,4,6-Trichlorophenylhydrazine”, Edgar, K.J.; Hyatt, J.A. U.S. 4,772,747 (1988).