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Kevin Edgar

Professor, Biomaterials and Bioprocessing; Director, ICTAS Bio-Based Materials Center; Ph.D. (Duke)
Headshot of Kevin Edgar
Sustainable Biomaterials
230 Cheatham Hall
Blacksburg, VA
24061
kjedgar@vt.edu
540-231-0674

Dr. Edgar's lab designs and creates derivatives of natural polysaccharides to address demanding performance requirements. They explore the structure-property-performance relationships of these materials, for diverse and demanding applications including drug-delivery systems, tissue engineering, biodegradable plastics, polymer compatibilization, hydrogels, and block copolymers. He is interested in novel methods to control and utilize the nanostructure of polysaccharides and derivatives, in particular the regioselective substitution reactions of complex polysaccharides, as well as the preparation of polysaccharides with controlled sequences.

His research more broadly addresses more effective ways of utilizing the vast abundance and diversity of natural polysaccharides to address societal needs. These sustainable, generally benign materials have an enormous variety of natural functions, ranging from structural, to rheology modification, to energy storage, to information storage and communication (glycosaminoglycans for example have the highest density of information storage of any natural polymer family, vastly greater than that of proteins and polynucleic acids like DNA and RNA). They have enormous potential for meeting challenging application demands while reducing the need for fossil fuel-based materials.

Edgar is active in the Macromolecules and Interfaces Institute (MII) and in the Institute for Critical Technologies and Applied Science (ICTAS). He is a member of the NSF sponsored Materials Innovation Platform focusing on glycoscience (GlycoMIP), and he is co-Director of the Infectious Disease Interdisciplinary Graduate Education Program (ID IGEP). He leads a track within the ICTAS Center for Engineered Health.

He is an editor-in-chief of the journal Carbohydrate Polymers, and a member of the editorial boards of the journals Biomacromolecules and Cellulose. He is an active member of the American Chemical Society and of its Division of Cellulose and Renewable Materials.

To learn more about Kevin, read this article from our series One of Us.

Area of Expertise

  • Creation of drug delivery systems to meet patient needs
  • Bioavailability enhancement
  • Selective synthesis of novel polysaccharide derivatives
  • Polysaccharide-based hydrogels and block copolymers
  • Polysaccharide chemistry
  • Structure-property-performance relationships 
  • Sustainable-based materials for demanding applications

Education

  • Ph.D. Organic Chemistry, Duke University, 1979
  • B.S. Chemistry, Bucknell University, 1975

Polysaccharide Chemistry – Conjoint and crosslisted class (Advanced Polysaccharide Chemistry, SBIO 5424G and CHEM 5424G; Polysaccharide Chemistry, SBIO 4424 and CHEM 4424)

GTA Workshop – GRAD 5004

 

 

“Regioselective Synthesis of Novel Cellulose Derivatives for Drug Delivery”, S. Carter Fox, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, Nov. 4, 2011.

“Regioselective synthesis of cellulose derivatives”, Daiqiang Xu, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2012.

“Chemical modification of alginates in organic media”, Siddhesh Pawar, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Synthesis of new pullulan derivatives for drug delivery, Junia M. Pereira, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Synthesis and Structure-property Evaluation of Novel Cellulosic Polymers as Amorphous Solid Dispersion Matrices for Enhanced Oral Drug Delivery”, Haoyu Liu, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2013.

“Regioselective Synthesis of Cellulose Esters”, Xueyan Zheng, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2014.

“Pullulan w-carboxyalkanoates for drug nanodispersions”, Jameison Rolle, Submitted in partial fulfillment of requirements for Masters of Science in Macromolecular Science and Engineering, 2015.

“Synthesis and applications of cellulose derivatives for drug delivery”, Joyann Marks, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2015.

“Regioselective synthesis of curdlan derivatives”, Ruoran Zhang, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2015.

“Chemical Modification of Cellulose Esters for Oral Drug Delivery”, Xiangtao Meng, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2016.

“Cellulose Esters and Cellulose Ether Esters for Oral Drug Delivery Systems”, H. Cigdem Arca, Submitted in partial fulfillment of requirements for Ph.D. in Macromolecular Science and Engineering, 2016.

“Design and Synthesis of Cellulose Ether Derivatives for Oral Drug Delivery”, Yifan Dong, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2017.

“Regioselective Synthesis of Polysaccharide-based Polyelectrolytes”, Shu Liu, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, 2017.

“Regioselective Chlorination of Cellulose Esters”, Chengzhe Gao, Submitted in partial fulfillment of requirements for M.S. in Chemistry, June 2018.

“Regioselective Synthesis of Glycosaminoglycan Analogs”, Chengzhe Gao, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, February 2019.

“Synthesis and Structure-Property Relationships of Polysaccharide-Based Block Copolymers and Hydrogels”, Junyi Chen, Submitted in partial fulfillment of requirements for Ph.D. in Chemistry, December 2019.

“Synthesis of Polysaccharide-based Biomaterials for Drug Delivery”, Yang Zhou, Submitted in partial fulfillment of requirements for Ph.D. in Sustainable Biomaterials, January 2023.

  • 2023 Student Zhenghao Zhai won 2023 Garth L. Wilkes Interdisciplinary Student Scholar Award from MII, Virginia Tech
  • 2023 Appointed to Virginia Tech Academy of Faculty Leadership
  • 2023 Student Stella Petrova received Graduate School Doctoral Assistantship award in Chemistry
  • 2023 Student Fiorella Mazzini won MII Fellowship for spring semester
  • 2022 Virginia Tech College of Natural Resources and Environment Outstanding Graduate Student Mentor Award
  • 2022 Student Yang Zhou received Outstanding Doctoral Student award from the College of Natural Resources and Environment
  • 2022 Student Mariel Gomez received Outstanding Undergraduate Student award from the College of Natural Resources and Environment
  • 2020 Virginia Tech College of Natural Resources and Environment Research Achievement Award
  • 2020 Student Chengzhe Gao received Graduate School Doctoral Assistantship award in Chemistry
  • 2019 Student Chengzhe Gao received Eastman Fellowship in Polymer Science
  • 2016 Student Yifan Dong received Eastman Award as outstanding graduate student from CELL
  • 2016 Anselme Payen Award for outstanding professional contributions to the science and chemical technology of cellulose and its allied products, from the Cellulose and Renewable Materials Division (CELL) of the American Chemical Society (ACS)
  • 2015 Student Xiangtao Meng received Eastman Award as outstanding graduate student from CELL
  • 2013 Student Haoyu Liu received Eastman Award as the outstanding graduate student from CELL
  • 2012 Student Daiqiang Xu received Eastman Award as the outstanding graduate student from CELL
  • 2010 Named Fellow of the ACS Division of Cellulose and Renewable Materials
  • 2009 Named Fellow of ACS (member of the inaugural class of ACS Fellows)

 

 

  • PFI:RFP Innovation of Materials Based on Sustainable Resources to Enhance Performance of Challenging Drugs and Drug Candidates. Investigators: Kevin J. Edgar (PI), Lynne S. Taylor (Co-PI). Sponsor: NSF. Duration: 2018-2021.
  •  
  • All-polysaccharide, self-assembling, self-healing nanogels for delivery of crop protection agents. Investigators: Kevin J. Edgar (PI), Charles E. Frazier (Co-PI), Wade Thomason (Co-PI). Sponsor: USDA NIFA. Duration: 2020-2023.
  •  
  • GlycoMIP (Materials Innovation Platform). Investigators: Maren Roman (PI), Kevin J. Edgar, et al. Sponsor: NSF. Duration: 2019-2024.
  •  
  • Collaborative Research: How do polymers dissolve? Identification of rate-limiting steps as a framework to design polymers with tailored dissolution. Investigators: Lynne Taylor (PI), Kevin J. Edgar (co-PI). Sponsor: NSF. Duration: 2022-2025.

 

 

  • Books Edited
  • Lead editor of ACS Symposium Series Book: “Polysaccharide Materials:  Performance by Design”, ACS Symposium Series No. 1017, 2009, K.J. Edgar, T. Heinze, C.M. Buchanan editors, American Chemical Society, Washington, D.C.
  •  
  • Editor of ACS Symposium Series Book: “Cellulose Solvents: for Analysis, Shaping, and Chemical Modification”, ACS Symposium Series No.1033, 2010, T.F. Liebert, T.J. Heinze, K.J. Edgar editors, American Chemical Society, Washington, D.C.

    Journal Special Issues Edited
  • 1. “Polysaccharides in Drug Delivery”, Edgar, K.J. guest editor, Cellulose 2007 pp 1-83.
  • 2. “Biopolymers for Life”, Fardim, P.; Murphy, S.M.; Edgar, K.J. guest editors, Carbohydrate Polymers 2014, 1-224.
  • 3. “Polysaccharides and Polysaccharide Products: From Basic Science to Applications”, EPNOE 2013, guest editors Navard, P.; Edgar, K.J., Carbohydrate Polymers 2015, 116, 1-314.
  • 4. “100th Anniversary of the Cellulose and Renewable Materials Division of the American Chemical Society”, Carbohydrate Polymers 2020 (guest editor with Tatiana Budtova)
  • 5. “Carbohydrate Polymers 40th Anniversary”, Carbohydrate Polymers 2022 (guest editor with Manuel Coimbra and John F. Kennedy)
  • 25. “Amphiphilic polysaccharides, polysaccharide-based hydrogels, and methods of manufacture”, Edgar, K.J.; Nichols, B.L.B.; Chen, J.; Frazier, C.E.; Norris, A.M. U.S. 11,384,161, (2022).
  •  
  • 24. “Polysaccharide derivatives and cross-metathesis processes for preparing them”, Edgar, K.J.; Meng, X. U.S. 10,851,179, (2020).
  •  
  • 23. “Cross-metathesized polysaccharide derivatives and processes for preparing them”, Edgar, K.J.; Meng, X.; Matson, J.B. U.S. Patent 10,738,134 (2020).
  •  
  • 22. “Regioselectively Substituted Cellulose Esters And Efficient Methods Of Preparing Them”, Edgar, K.J.; Xu, D.; Zheng, X. U.S. Patent 9,624,311 (2017)
  •  
  • 21. “Esters Of Cellulosic Materials And Diacids And Method Of Making Thereof”, U.S. Patent 9,708,415 (2017)
  •  
  • 20. “Carbohydrate Esters and Polyol Esters as Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. U.S. 7,276,546 (2007).
  •  
  • 19. “Carbohydrate Esters and Polyol Esters as Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. U.S. 6,977,275 (2005).
  •  
  • 18. “Novel Carbohydrate Esters and Polyol Plasticizers for Polymers, Compositions and Articles Including Such Plasticizers and Methods of Using the Same”, Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L. US 6,977,275 (2005).

  • 17. “Process for Preparing Cellulose Esters Using a Sulfonic Acid Catalyst”, Edgar, K.J., US 6,160,111 (2000).

  • 16.  “Process for the Co-production of Dissolving Grade Pulp and Xylan”, Hyatt, J.A.; Fengl, R.W.; Edgar, K.J.; Alvarez-Wright, M.T., US 6,057,438 (2000).

  • 15.  “Direct Process for the Production of Cellulose Esters”, Edgar, K.J.; Bogan, R.T., US 5,929,229 (1999).

  • 14.  “Process for Preparing Cellulose Acetoacetate Alkanoates”, Kuo, C.M.; Edgar, K.J., US 5,770,726 (1998).

  • 13.  “Direct Process for the Production of Cellulose Esters”, Edgar, K.J.; Bogan, R.T., US 5,750,677 (1998).

  • 12.  “Process for Preparing Cellulose Esters by Use of Carboxylic Acids”, Edgar, K.J.; Buchanan, C.M. U.S. 5,597,912 (1997).

  • 11.  “Cellulose Acetoacetate Esters Used in Coating Compositions”, Edgar, K.J.; Lawniczak, J.E. US 5,595,591 (1997).

  • 10.  “Cellulose Acetoacetate Esters”, Edgar, K.J.; Lawniczak, J.E. U.S. 5,521,304 (1996).

  • 9.  “Cellulose Acetoacetate Esters”, Edgar, K.J.; Lawniczak, J.E. U.S. 5,420,267 (1995).

  • 8.  “Cellulose Acetoacetates”, Edgar, K.J.; Blount, Jr., W.W. U.S. 5,360,843 (1994).

  • 7.  “Miscible Blends of Cellulose Esters and Vinylphenol Containing Polymers”, Landry, C.J.T.; Teegarden, D.M.; Edgar, K.J.; Kelley, S.S. U.S. 5,302,637 (1994).

  • 6.  “Cellulose Acetoacetates”, Edgar, K.J.; Blount, Jr., W.W. U.S. 5,292,877 (1994).

  • 5.  “Cellulose Ester Compositions and Process for the Preparation Thereof”, Bellas, M.; Buchanan, C.M.; Edgar, K.J.; Germroth, T.C.; Wilson, A.W. U.S. 5,142,034 (1992).

  • 4.  “Process for the Iodination of Hydroxyaromatic and Aminoaromatic Compounds”, Edgar, K.J.; Steinmetz, G.R. U.S. 4,997,946 (1991).

  • 3.  “Preparation of 4-Substituted Aryl Olefins”, Edgar, K.J. U.S. 4,965,361 (1990).

  • 2.  “Process for the Carbonylation of Iodoaromatic Compounds”, Steinmetz, G.R.; Edgar, K.J.; Falling, S.N. U.S. 4, 885,384 (1989).

  • 1.  “Preparation of 2,4,6-Trichlorophenylhydrazine”, Edgar, K.J.; Hyatt, J.A. U.S. 4,772,747 (1988).

Recent examples from among 122 total refereed publications (graduate student authors indicated by asterisk*, undergraduate authors indicated by carat^):

140. Novo, D.C.; Edgar, K.J. Smart Fluorescent Polysaccharides: Recent Developments and Applications. Carbohydrate Polymers 2024, 324, 121471. doi.org/10.1016/j.carbpol.2023.121471.

139. Thompson, J.E.; Mazzini, F.; Yazdi, Z.; Edgar, K.J. Cellulose Esters, Organic. Chapter in Encyclopedia of Polymer Science & Technology. 2023, Wiley.

138. Chen, J.; Edgar, K.J. Synthetic Routes to Hydrogels and Polysaccharide-Based Block Copolymers. In Sustainable Green Chemistry in Polymer Research Volume 1, ACS Symposium Series, American Chemical Society, 2023.

137. Zhai, Zhenghao; Zhou, Y.; Korovich, A.G.; Hall, B.A.; Yoon, H.Y.; Yao, Y.; Zhang, J.; Bortner, M.J.; Roman, M.; Madsen, L.A.; Edgar, K.J. Synthesis and characterization of multi-reducing end polysaccharides. Biomacromolecules2023, 24, accepted for publication. https://doi.org/10.1021/acs.biomac.3c00104

 

136. Knight, B.M.; Edgar, K.J.; De Yoreo, J.J.; Dove, P.M. Chitosan as a canvas for studies of macromolecular controls on CaCO3 biological crystallization. Biomacromolecules 2023, 24, 1078-1102. https://doi.org/10.1021/acs.biomac.2c01394

 

135. Weyhrich, C.; Petrova, S.P.; Edgar, K.J.; Long, T.E. Renewed Interest in Biopolymer Composites: Incorporation of Renewable, Plant-Sourced Fibers, Green Chemistry, 2023, 25, 106-129. DOI: 10.1039/D2GC03384D

 

134. Zhou, Y.; Zhai, Z.; Yao, Y.; Stant, J.C.; Landrum, S.L.; Bortner, M.J.; Frazier, C.E.; Edgar, K.J. Oxidized hydroxypropyl cellulose / carboxymethyl chitosan hydrogels permit pH-responsive, targeted drug release. Carbohydr. Polym. 2023, 300, 120213. https://doi.org/10.1016/j.carbpol.2022.120213

 

133. Chen, J.; Zhai, Z.; Edgar, K.J. Recent advances in polysaccharide-based in situ forming hydrogels. Current Opinion in Chemical Biology 2022, 70, 102200. https://doi.org/10.1016/j.cbpa.2022.102200.

 

132. Yang Shen, Y.; Zhang, H.; Edgar, K.J., Yang, G.; Shao, H. Effect of Lyocell fiber cross-sectional shape on structure and properties of Lyocell/PLA composites. J. Polymer Engineering 2022, 42, 868-875. https://doi.org/10.1515/polyeng-2022-0070

 

131. Novo, D.C.; Gao, C.; Qi, Q.; Mosquera-Giraldo, L.I.; Spiering, G.A.; Moore, R.B.; Taylor, L.S.; Edgar, K.J. Designing synergistic crystallization inhibitors: bile salt derivatives of cellulose with enhanced hydrophilicity. Carbohyr. Polym. 2022, 292, 192680. https://doi.org/10.1016/j.carbpol.2022.119680

 

130. Zhou, Y.; Edgar, K.J. Regioselective synthesis of polysaccharide–amino acid ester conjugates. Carbohydr. Polym.2022, 277, 118886. https://doi.org/10.1016/j.carbpol.2021.118886

 

129. Chen, J.; Edgar, K.J. In situ forming hydrogels based on oxidized hydroxypropyl cellulose and Jeffamines. Cellulose 2021, 28, 11367-11380. DOI: https://doi.org/10.1007/s10570-021-04272-0.

 

128. Zhou, Y.; Petrova, S.P.; Edgar, K.J. Chemical Synthesis of Polysaccharide–Protein and Polysaccharide–Peptide Conjugates: A Review Carbohydr. Polym. 2021, 274, 118662. https://doi.org/10.1016/j.carbpol.2021.118662.

 

127. Zhang, H.; Li, Q.; Edgar, K.J.; Yang, G.; Shao, H. Structure and properties of flax vs. Lyocell fiber-reinforced polylactide stereocomplex composites. Cellulose 2021, 28, 9297-9308. https://doiorg/10.1007/s10570-021-04105-0.

 

126. Wilson, V.; Mugheirbi, N.; Mosquera-Giraldo, L.I.; Deac, A.; Moseson, D.; Smith, D.; Novo, D.; Borca, C.; Slipchenko, L.; Edgar, K.J.; Taylor, L.S. Interaction of Polymers with Enzalutamide Nanodroplets – Impact on Droplet Properties and Induction Times. Mol. Pharm. 2021, 18, 836-849. doi.org/10.1021/acs.molpharmaceut.0c00833

 

125. Zhang, H.-H.; Yang, G.; Edgar, K.J.; Zhong, G.; Liu, P.; Li, M.; Shao, H. Preparation and properties of dual-wavelength excitable fluorescent Lyocell fibers and their applications in papermaking. Carbohydrate Polymers 2021, 261, 117861. doi.org/10.1016/j.carbpol.2021.117861

 

124. Chen, J.; Ma, X.; Edgar, K.J. A Versatile Method for Preparing Polysaccharide Conjugates via Thiol-Michael Addition. Polymers 2021, 13, 1905 doi.org/10.3390/polym13121905

 

123. Chen, J.; Frazier, C.E.; Edgar, K.J. Photo-curable, double-crosslinked, in situ-forming hydrogels based on oxidized hydroxypropyl cellulose. Cellulose 2021, 28, 3903-3915. doi.org/10.1007/s10570-021-03788-9.

 

122. Zhang, H.-H.; Shen, Y.; Edgar, K.J.; Yang, G.; Shao, H. Influence of the Cross-section Shape on the Structure and Properties of Lyocell fibers. Cellulose 2021, 28, 1191-1201. doi.org/10.1007/s10570-020-03605-9

 

121. Edgar, K.J.; Marks, J.A. Green Hydrogels Based on Starch: Preparation Methods for Biomedical Applications. 2020. In Sustainability & Green Polymer Chemistry Volume 1: Green Products and Processes , ACS Symposium Series 1372, pp. 173-196. American Chemical Society.

 DOI: 10.1021/bk-2020-1372.ch010

 

120. Chen, J.; Kamitakahara, H.; Edgar, K.J. Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis. Carbohydr. Polym. 2020, 229, 115530. doi.org/10.1016/j.carbpol.2019.115530

 

119. Volokhova, A.; Edgar, K.J.; Matson, J.B. Polysaccharide-containing block copolymers: synthesis and applications. Mater. Chem. Front. 2020, 4, 99-112. DOI: 10.1039/C9QM00481E

 

118. Nichols, B.L.B.; Chen, J.; Mischnick, P.; Edgar, K.J. Selective oxidation of hydroxypropyl ethers of cellulose and dextran. Simple and efficient introduction of versatile ketone groups to polysaccharide. Biomacromolecules, 2020, 21, 4835-4849. doi.org/10.1021/acs.biomac.0c01045.

 

117. Hettegger, H.; Steinkellner, K.; Zwirchmayr, N.S.; Potthast, A.; Edgar, K.J.; Rosenau, T. Reaction of 2,5-dihydroxy-[1,4]-benzoquinone with nucleophiles – ipso-substitution vs. addition/elimination. Chem. Commun. 2020, 56, 12845-12848. DOI: 10.1039/D0CC04748A.

 

116. Wilson, V.; Lou, X.; Osterling, D.; Stolarik, D.; Jenkins, G.; Nichols, B.; Dong, Y.; Edgar, K.J.; Zhang, G.; Taylor, L.S. Amorphous Solid Dispersions of Enzalutamide and Novel Polysaccharide Derivatives: Investigation of Relationships between Polymer Structure and Performance, Scientific Reports, 2020, 10, 18535. doi.org/10.1038/s41598-020-75077-7.

 

115. Chen, J.; Nichols, B.L.B.; Norris, A.M.; Frazier, C.E.; Edgar, K.J. All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides. Biomacromolecules 2020, 21, 4262-4272. doi.org/10.1021/acs.biomac.0c01046

 

114. Zhang, H.-H.; Edgar, K.J. Antibacterial modification of Lyocell fiber: A review. Carbohydr. Polym., 2020, 250, 116932. doi.org/10.1016/j.carbpol.2020.116932

 

113. Chen, J.; Spiering, G.; Mosquera-Giraldo, L; Moore, R.B.; Edgar, K.J. Regioselective bromination of the dextran non-reducing end creates a pathway to dextran-based block copolymers. Biomacromolecules 2020, 21, 1729-1738. doi.org/10.1021/acs.biomac.9b01668

 

112. Ho, D.-K.; Nichols, B.; Edgar, K.J.; Murgia, X.; Loretz, B.; Lehr, C.-M. Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections. Eur. J. Pharm. Biopharm. 2019, 144, 110-124. doi.org/10.1016/j.ejpb.2019.09.002

 

111. Chen, J.; Kamitakahara, H.; Edgar, K.J. Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis. Carbohydr. Polym. 2019, 229, 115530. doi.org/10.1016/j.carbpol.2019.115530

 

110. Dong, Y.; Novo, D.C.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Conjugation of Bile Esters to Cellulose by Olefin Cross-metathesis: A Strategy for Accessing Complex Polysaccharide Structures. Carbohydr. Polym. 2019, 144, 110-124. doi.org/10.1016/j.carbpol.2019.05.061

 

109. Arrington, K.J.; Haag, J.V.; French, E.V.; Murayama, M.; Edgar, K.J.; Matson, J.B. Toughening cellulose: compatibilizing polybutadiene and cellulose triacetate blends. ACS Macro Letters 2019, 8, 447-453. doi.org/10.1021/acsmacrolett.9b00136

 

108. Gao, C.; Fisher, Z.B.; Edgar, K.J. Azide reduction by DTT or thioacetic acid provides access to amino and amido polysaccharides. Cellulose 2019, 26, 445-462. doi.org/10.1007/s10570-018-2195-3

 

107. Mosquera-Giraldo, L.I.; Borca, C.H.; Parker, A.S.; Dong, Y.; Edgar, K.J.; Beaudoin, S.P.; Slipchenko, L.V.; Taylor, L.S. Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules 2018, 19, 4593-4606. doi.org/10.1021/acs.biomac.8b01280

 

106. Gao, C.; Edgar, K.J. Efficient Synthesis of Glycosaminoglycan Analogs. Biomacromolecules, 2019, 20, 608-617. doi.org/10.1021/acs.biomac.8b01150

 

105. Arca, H.C.; Mosquera-Giraldo, L.I.; Bi, V.; Xu, D.; Taylor, L.S.; Edgar, K.J. Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules 2018, 19, 2351-2376. doi.org/10.1021/acs.biomac.8b00517

 

104. Gao, C.; Liu, S.; Edgar, K.J. Regioselective chlorination of cellulose esters by methanesulfonyl chloride. Carbohydr. Polym. 2018, 193, 108-118. doi.org/10.1016/j.carbpol.2018.03.093

 

103. Mosquera-Giraldo, L.I.; Li, N.; Wilson, V.; Nichols, B.L.B.; Edgar, K.J.; Taylor, L.S. Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Mol. Pharm. 2018, 15, 1700-1713. doi.org/10.1021/acs.molpharmaceut.8b00104

 

102. Liu, S.; Gao, C.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Selective Synthesis of Curdlan w-Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydr. Polym., 2018, 190, 222-231. doi.org/10.1016/j.carbpol.2018.02.074

 

101. Amin, M.; Abbas, N.S.; Hussain, M.A.; Sher, M.; Edgar, K.J. Design of cellulose ether-based macromolecular prodrugs of ciprofloxacin for extended release and enhanced bioavailability. Int. J. Biol. Macromol., 2018, 113, 719-728. doi.org/10.1016/j.ijbiomac.2018.02.142

 

100. Winslow, C.; Nichols, B.L.B.; Novo, D.; Mosquera-Giraldo; L.I.; Taylor, L.S.; Edgar, K.J.; Neilson, A.P. Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydr. Polym., 2018, 182, 149-158. doi.org/10.1016/j.carbpol.2017.11.024

 

99. Arca, H.C.; Mosquera-Giraldo, L.I.; Pereira, J.M.; Sriranganathan, N.; Taylor, L.S.; Edgar, K.J. Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose w-Carboxyalkanoate Matrices. J. Pharm. Sci. 2018, 107, 127-138. doi.org/10.1016/j.xphs.2017.05.036

  • Refereed Publications at Virginia Tech:
  •  
  • 137. Zhai, Zhenghao; Zhou, Y.; Korovich, A.G.; Hall, B.A.; Yoon, H.Y.; Yao, Y.; Zhang, J.; Bortner, M.J.; Roman, M.; Madsen, L.A.; Edgar, K.J. Synthesis and characterization of multi-reducing end polysaccharides. Biomacromolecules2023, 24, accepted for publication. https://doi.org/10.1021/acs.biomac.3c00104
  •  
  • 136. Knight, B.M.; Edgar, K.J.; De Yoreo, J.J.; Dove, P.M. Chitosan as a canvas for studies of macromolecular controls on CaCO3 biological crystallization. Biomacromolecules 2023, 24, 1078-1102. https://doi.org/10.1021/acs.biomac.2c01394
  •  
  • 135. Weyhrich, C.; Petrova, S.P.; Edgar, K.J.; Long, T.E. Renewed Interest in Biopolymer Composites: Incorporation of Renewable, Plant-Sourced Fibers, Green Chemistry, 2023, 25, 106-129. DOI: 10.1039/D2GC03384D
  •  
  • 134. Zhou, Y.; Zhai, Z.; Yao, Y.; Stant, J.C.; Landrum, S.L.; Bortner, M.J.; Frazier, C.E.; Edgar, K.J. Oxidized hydroxypropyl cellulose / carboxymethyl chitosan hydrogels permit pH-responsive, targeted drug release. Carbohydr. Polym. 2023, 300, 120213. https://doi.org/10.1016/j.carbpol.2022.120213
  •  
  • 133. Chen, J.; Zhai, Z.; Edgar, K.J. Recent advances in polysaccharide-based in situ forming hydrogels. Current Opinion in Chemical Biology 2022, 70, 102200. https://doi.org/10.1016/j.cbpa.2022.102200.
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  • 132. Yang Shen, Y.; Zhang, H.; Edgar, K.J., Yang, G.; Shao, H. Effect of Lyocell fiber cross-sectional shape on structure and properties of Lyocell/PLA composites. J. Polymer Engineering 2022, 42, 868-875. https://doi.org/10.1515/polyeng-2022-0070
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  • 131. Novo, D.C.; Gao, C.; Qi, Q.; Mosquera-Giraldo, L.I.; Spiering, G.A.; Moore, R.B.; Taylor, L.S.; Edgar, K.J. Designing synergistic crystallization inhibitors: bile salt derivatives of cellulose with enhanced hydrophilicity. Carbohyr. Polym. 2022, 292, 192680. https://doi.org/10.1016/j.carbpol.2022.119680
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  • 130. Zhou, Y.; Edgar, K.J. Regioselective synthesis of polysaccharide–amino acid ester conjugates. Carbohydr. Polym.2022, 277, 118886. https://doi.org/10.1016/j.carbpol.2021.118886
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  • 129. Chen, J.; Edgar, K.J. In situ forming hydrogels based on oxidized hydroxypropyl cellulose and Jeffamines. Cellulose 2021, 28, 11367-11380. DOI: https://doi.org/10.1007/s10570-021-04272-0.
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  • 128. Zhou, Y.; Petrova, S.P.; Edgar, K.J. Chemical Synthesis of Polysaccharide–Protein and Polysaccharide–Peptide Conjugates: A Review Carbohydr. Polym. 2021, 274, 118662. https://doi.org/10.1016/j.carbpol.2021.118662.
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  • 127. Zhang, H.; Li, Q.; Edgar, K.J.; Yang, G.; Shao, H. Structure and properties of flax vs. Lyocell fiber-reinforced polylactide stereocomplex composites. Cellulose 2021, 28, 9297-9308. https://doiorg/10.1007/s10570-021-04105-0.
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  • 126. Wilson, V.; Mugheirbi, N.; Mosquera-Giraldo, L.I.; Deac, A.; Moseson, D.; Smith, D.; Novo, D.; Borca, C.; Slipchenko, L.; Edgar, K.J.; Taylor, L.S. Interaction of Polymers with Enzalutamide Nanodroplets – Impact on Droplet Properties and Induction Times. Mol. Pharm. 2021, 18, 836-849. doi.org/10.1021/acs.molpharmaceut.0c00833
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  • 125. Zhang, H.-H.; Yang, G.; Edgar, K.J.; Zhong, G.; Liu, P.; Li, M.; Shao, H. Preparation and properties of dual-wavelength excitable fluorescent Lyocell fibers and their applications in papermaking. Carbohydrate Polymers 2021, 261, 117861. doi.org/10.1016/j.carbpol.2021.117861
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  • 124. Chen, J.; Ma, X.; Edgar, K.J. A Versatile Method for Preparing Polysaccharide Conjugates via Thiol-Michael Addition. Polymers 2021, 13, 1905 doi.org/10.3390/polym13121905
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  • 123. Chen, J.; Frazier, C.E.; Edgar, K.J. Photo-curable, double-crosslinked, in situ-forming hydrogels based on oxidized hydroxypropyl cellulose. Cellulose 2021, 28, 3903-3915. doi.org/10.1007/s10570-021-03788-9.
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  • 122. Zhang, H.-H.; Shen, Y.; Edgar, K.J.; Yang, G.; Shao, H. Influence of the Cross-section Shape on the Structure and Properties of Lyocell fibers. Cellulose 2021, 28, 1191-1201. doi.org/10.1007/s10570-020-03605-9
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  • 121. Edgar, K.J.; Marks, J.A. Green Hydrogels Based on Starch: Preparation Methods for Biomedical Applications. 2020. In Sustainability & Green Polymer Chemistry Volume 1: Green Products and Processes , ACS Symposium Series 1372, pp. 173-196. American Chemical Society.
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  • 120. Chen, J.; Kamitakahara, H.; Edgar, K.J. Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis. Carbohydr. Polym. 2020, 229, 115530. doi.org/10.1016/j.carbpol.2019.115530
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  • 119. Volokhova, A.; Edgar, K.J.; Matson, J.B. Polysaccharide-containing block copolymers: synthesis and applications. Mater. Chem. Front. 2020, 4, 99-112. DOI: 10.1039/C9QM00481E
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  • 118. Nichols, B.L.B.; Chen, J.; Mischnick, P.; Edgar, K.J. Selective oxidation of hydroxypropyl ethers of cellulose and dextran. Simple and efficient introduction of versatile ketone groups to polysaccharide. Biomacromolecules, 2020, 21, 4835-4849. doi.org/10.1021/acs.biomac.0c01045.
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  • 117. Hettegger, H.; Steinkellner, K.; Zwirchmayr, N.S.; Potthast, A.; Edgar, K.J.; Rosenau, T. Reaction of 2,5-dihydroxy-[1,4]-benzoquinone with nucleophiles – ipso-substitution vs. addition/elimination. Chem. Commun. 2020, 56, 12845-12848. DOI: 10.1039/D0CC04748A.
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  • 116. Wilson, V.; Lou, X.; Osterling, D.; Stolarik, D.; Jenkins, G.; Nichols, B.; Dong, Y.; Edgar, K.J.; Zhang, G.; Taylor, L.S. Amorphous Solid Dispersions of Enzalutamide and Novel Polysaccharide Derivatives: Investigation of Relationships between Polymer Structure and Performance, Scientific Reports, 2020, 10, 18535. doi.org/10.1038/s41598-020-75077-7.
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  • 115. Chen, J.; Nichols, B.L.B.; Norris, A.M.; Frazier, C.E.; Edgar, K.J. All-polysaccharide, self-healing injectable hydrogels based on chitosan and oxidized hydroxypropyl polysaccharides. Biomacromolecules 2020, 21, 4262-4272. doi.org/10.1021/acs.biomac.0c01046
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  • 114. Zhang, H.-H.; Edgar, K.J. Antibacterial modification of Lyocell fiber: A review. Carbohydr. Polym., 2020, 250, 116932. doi.org/10.1016/j.carbpol.2020.116932
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  • 113. Chen, J.; Spiering, G.; Mosquera-Giraldo, L; Moore, R.B.; Edgar, K.J. Regioselective bromination of the dextran non-reducing end creates a pathway to dextran-based block copolymers. Biomacromolecules 2020, 21, 1729-1738. doi.org/10.1021/acs.biomac.9b01668
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  • 112. Ho, D.-K.; Nichols, B.; Edgar, K.J.; Murgia, X.; Loretz, B.; Lehr, C.-M. Challenges and Strategies in Drug Delivery Systems for Treatment of Pulmonary Infections. Eur. J. Pharm. Biopharm. 2019, 144, 110-124. doi.org/10.1016/j.ejpb.2019.09.002
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  • 111. Chen, J.; Kamitakahara, H.; Edgar, K.J. Synthesis of polysaccharide-based block copolymers via olefin cross-metathesis. Carbohydr. Polym. 2019, 229, 115530. doi.org/10.1016/j.carbpol.2019.115530
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  • 110. Dong, Y.; Novo, D.C.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Conjugation of Bile Esters to Cellulose by Olefin Cross-metathesis: A Strategy for Accessing Complex Polysaccharide Structures. Carbohydr. Polym. 2019, 144, 110-124. doi.org/10.1016/j.carbpol.2019.05.061
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  • 109. Arrington, K.J.; Haag, J.V.; French, E.V.; Murayama, M.; Edgar, K.J.; Matson, J.B. Toughening cellulose: compatibilizing polybutadiene and cellulose triacetate blends. ACS Macro Letters 2019, 8, 447-453. doi.org/10.1021/acsmacrolett.9b00136
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  • 108. Gao, C.; Fisher, Z.B.; Edgar, K.J. Azide reduction by DTT or thioacetic acid provides access to amino and amido polysaccharides. Cellulose 2019, 26, 445-462. doi.org/10.1007/s10570-018-2195-3
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  • 107. Mosquera-Giraldo, L.I.; Borca, C.H.; Parker, A.S.; Dong, Y.; Edgar, K.J.; Beaudoin, S.P.; Slipchenko, L.V.; Taylor, L.S. Crystallization Inhibition Properties of Cellulose Esters and Ethers for a Group of Chemically Diverse Drugs - Experimental and Computational Insight. Biomacromolecules 2018, 19, 4593-4606. doi.org/10.1021/acs.biomac.8b01280
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  • 106. Gao, C.; Edgar, K.J. Efficient Synthesis of Glycosaminoglycan Analogs. Biomacromolecules, 2019, 20, 608-617. doi.org/10.1021/acs.biomac.8b01150
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  • 105. Arca, H.C.; Mosquera-Giraldo, L.I.; Bi, V.; Xu, D.; Taylor, L.S.; Edgar, K.J. Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters. Biomacromolecules 2018, 19, 2351-2376. doi.org/10.1021/acs.biomac.8b00517
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  • 104. Gao, C.; Liu, S.; Edgar, K.J. Regioselective chlorination of cellulose esters by methanesulfonyl chloride. Carbohydr. Polym. 2018, 193, 108-118. doi.org/10.1016/j.carbpol.2018.03.093
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  • 103. Mosquera-Giraldo, L.I.; Li, N.; Wilson, V.; Nichols, B.L.B.; Edgar, K.J.; Taylor, L.S. Influence of Polymer and Drug Loading on the Release Profile and Membrane Transport of Telaprevir. Mol. Pharm. 2018, 15, 1700-1713. doi.org/10.1021/acs.molpharmaceut.8b00104
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  • 102. Liu, S.; Gao, C.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Selective Synthesis of Curdlan w-Carboxyamides by Staudinger Ylide Nucleophilic Ring-opening. Carbohydr. Polym., 2018, 190, 222-231. doi.org/10.1016/j.carbpol.2018.02.074
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  • 101. Amin, M.; Abbas, N.S.; Hussain, M.A.; Sher, M.; Edgar, K.J. Design of cellulose ether-based macromolecular prodrugs of ciprofloxacin for extended release and enhanced bioavailability. Int. J. Biol. Macromol., 2018, 113, 719-728. doi.org/10.1016/j.ijbiomac.2018.02.142
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  • 100. Winslow, C.; Nichols, B.L.B.; Novo, D.; Mosquera-Giraldo; L.I.; Taylor, L.S.; Edgar, K.J.; Neilson, A.P. Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro. Carbohydr. Polym., 2018, 182, 149-158. doi.org/10.1016/j.carbpol.2017.11.024
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  • 99. Abbas, Khawar; Amin, Muhammad; Hussain, Muhammad Ajaz; Sher, Muhammad; Bukhari, Syed Nasir Abbas; Edgar, K.J. Design, characterization and pharmaceutical/pharmacological applications of ibuprofen conjugates based on hydroxyethylcellulose. RSC Advances, 2017, 7, 50672-50679. DOI: 10.1039/C7RA08502H
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  • 98. Arca, H.C.; Mosquera-Giraldo, L.I.; Dahal, D.; Taylor, L.S.; Edgar, K.J. Multidrug, anti-HIV amorphous solid dispersions: nature and mechanisms of impacts of drugs on each other’s solution concentrations. Mol. Pharm. 2017, 14, 3617-3627. doi.org/10.1021/acs.molpharmaceut.7b00203
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  • 97. Arca, H.C.; Mosquera-Giraldo, L.I.; Pereira, J.M.; Sriranganathan, N.; Taylor, L.S.; Edgar, K.J. Rifampin Stability and Solution Concentration Enhancement through Amorphous Solid Dispersion in Cellulose w-Carboxyalkanoate Matrices. J. Pharm. Sci. 2018, 107, 127-138. doi.org/10.1016/j.xphs.2017.05.036
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  • 96. Abbas, K.; Amin, M.; Hussain, M.A.; Sher, M.; Bukhari, S.N.A.; Jantan, I.; Edgar, K.J. Designing Novel Bioconjugates of Hydroxyethylcellulose and Salicylates for Potential Pharmaceutical and Pharmacological Applications. Int. J. Biol. Macromol. 2017, 103, 441-450. doi.org/10.1016/j.ijbiomac.2017.05.061
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  • 95. Dong, Y.; Matson, J.B.; Edgar, K.J. Olefin Cross-Metathesis in Polymer and Polysaccharide Chemistry: A Review. Biomacromolecules 2017, 18, 1661-1676. doi.org/10.1021/acs.biomac.7b00364
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  • 94. Zhang, R.; Liu, S.; Edgar, K.J. Efficient Synthesis of Secondary Amines by Reductive Amination of Curdlan Staudinger Ylides. Carbohydr. Polym. 2017, 171, 1-8. doi.org/10.1016/j.carbpol.2017.04.093
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  • 93. Dong, Y.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Tandem Modification of Amphiphilic Cellulose Ethers for Amorphous Solid Dispersion via Olefin Cross-metathesis and Thiol-Michael Addition. Polym. Chem., 2017, 8, 3129-3139. DOI: 10.1039/C7PY00228A
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  • 92. Liu, S.; Edgar, K.J. Water-Soluble Co-polyelectrolytes by Selective Modification of Cellulose Esters. Carbohydrate Polymers, 2017, 162, 1-9. doi.org/10.1016/j.carbpol.2017.01.008
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  • 91. Arca, H.C.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Synthesis and Characterization of Alkyl Cellulose ω-Carboxyesters for Amorphous Solid Dispersion. Cellulose 2017, 24, 609-625. DOI 10.1007/s10570-016-1156-y
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  • 90. Mosquera-Giraldo, L.I.; Borca, C.H.; Meng, X.; Edgar, K.J.; Slipchenko, L.V.; Taylor, L.S. Mechanistic Design of Chemically Diverse Polymers with Applications in Oral Drug Delivery. Biomacromolecules, 2016, 17, 3659-3671. doi.org/10.1021/acs.biomac.6b01156
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  • 89. Gilley, A.D.; Arca, H.C.; Nichols, B.L.B.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J.; Neilson, A.P. Novel Cellulose-Based Amorphous Solid Dispersions Enhance Quercetin Solution Concentrations In Vitro. Carbohydrate Polymers, 2017, 157, 86-93. doi.org/10.1016/j.carbpol.2016.09.067
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  • 88. Dong, Y.; Mosquera-Giraldo, L.I.; Troutman, J.; Skogstad, B.; Taylor, L.S.; Edgar, K.J. Amphiphilic Hydroxyalkyl Cellulose Derivatives for Amorphous Solid Dispersion Prepared by Olefin Cross-Metathesis. Polymer Chemistry, 2016, 7, 4953-4963. DOI: 10.1039/C6PY00960C
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  • 87. Meng, X.; Choudhury, S.R.; Edgar, K.J. Multifunctional cellulose esters by olefin cross-metathesis and thiol-Michael addition. Polym. Chem. 2016, 7, 3848-3856. DOI: 10.1039/C6PY00539J
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  • 86. Marks, J.A.; Fox, S.C.; Edgar, K.J. Cellulosic Polyelectrolytes: Synthetic Pathways to Regioselectively Substituted Ammonium and Phosphonium Derivatives. Cellulose 2016, 23, 1687–1704. doi.org/10.1007/s10570-016-0929-7
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  • 85. Codera, V.; Edgar, K.J.; Faijes, M.; Planas, A. Functionalized celluloses with regular substitution pattern by glycosynthase-catalyzed polymerization. Biomacromolecules 2016, 17, 1272-1279. doi.org/10.1021/acs.biomac.5b01453
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  • 84. Liu, S.; Liu, J.; Esker, A.; Edgar, K.J. An Efficient, Regioselective Pathway to Cationic and Zwitterionic N-Heterocyclic Cellulose Ionomers. Biomacromolecules, 2016, 17, 503-513. doi.org/10.1021/acs.biomac.5b01416
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  • 83. Dong, Y.; Mosquera-Giraldo, L.I.; Taylor, L.S.; Edgar, K.J. Amphiphilic Cellulose Ethers Designed for Amorphous Solid Dispersion via Olefin Cross-Metathesis. Biomacromolecules, 2016, 17, 454-465. doi.org/10.1021/acs.biomac.5b01336
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  • 82. Abbas, N.S.; Amin, M.; Hussain, M.A.; Edgar, K.J.; Tahir, M.N.; Tremel, W. Extended release and enhanced bioavailability of moxifloxacin conjugated with hydrophilic cellulose ethers. Carbohydrate Polymers 2016, 136, 1297-1306. doi.org/10.1016/j.carbpol.2015.10.052
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  • 81. Liu, H.; Taylor, L.S.; Edgar, K.J. The role of polymers in oral bioavailability enhancement; a review. Polymer 2015, 77, 319-415. doi.org/10.1016/j.polymer.2015.09.026
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  • 80. Zhang, R.; Liu, S.; Edgar, K.J. Regioselective synthesis of cationic 6-(N, N, N-trialkylammonio)-6-deoxycurdlan derivatives. Carbohydrate Polymers, 2016, 136, 474-484. doi.org/10.1016/j.carbpol.2015.09.011
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  • 79. Liu, S.; Edgar, K.J. Staudinger Reactions for Selective Functionalization of Polysaccharides: A Review.Biomacromolecules, 2015, 16, 2556-2571. doi.org/10.1021/acs.biomac.5b00855
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  • 78. Meng, X.; Edgar, K.J. “Click” reactions in polysaccharide modification. Progress in Polymer Science, 2016, 53, 52-85. doi.org/10.1016/j.progpolymsci.2015.07.006
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  • 77. Meng, X.; York, E.A.; Liu, S.; Edgar, K.J. Hydroboration-Oxidation: A Chemoselective Route to Cellulose w-Hydroxyalkanoate Esters. Carbohydr. Polym., 2015, 133, 262-269. doi.org/10.1016/j.carbpol.2015.06.080
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  • 76. Meng, X.; Edgar, K.J. Synthesis of amide-functionalized cellulose esters by olefin cross-metathesis. Carbohydr. Polym., 2015, 132, 565-573. doi.org/10.1016/j.carbpol.2015.06.052
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  • 75. Wegeil, L.A.; Mauer, L., Mosquera-Giraldo, L.; Edgar, K.J.; Taylor, L.S. Phase Behavior of Resveratrol Solid Dispersions Upon Addition to Aqueous Media. Pharm. Res., 2015, 32, 3324-3337. doi.org/10.1007/s11095-015-1709-z
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  • 74. Dong, Y.; Edgar, K.J. Imparting functional variety to cellulose ethers via olefin cross-metathesis. Polymer Chemistry 2015, 6, 3816-3827. DOI: 10.1039/C5PY00369E
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  • 73. Amin, M.; Abbas, N.S.; Hussain, M.A.; Edgar, K.J.; Tahir, M.N.; Tremel, W.; Sher, M. Cellulose ether derivatives: A new platform for prodrug formation of fluoroquinolone antibiotics. Cellulose 2015, 22, 2011-2022. doi.org/10.1007/s10570-015-0625-z
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  • 72. Vaidya, P.; Grove, T.; Edgar, K.J.; Goldstein, A.S. Surface Grafting of Chitosan Shell, Polycaprolactone Core Fiber Meshes to Confer Bioactivity. Journal of Bioactive and Compatible Polymers, 2015, 1-17. doi.org/10.1177/0883911515571147
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  • 71. Zhang, R.; Edgar, K.J., Water-soluble amino- and amidocurdlan derivatives by chemoselective azide reduction using NaBH4. Carbohydr. Polym. 2015, 122, 84-92. doi.org/10.1016/j.carbpol.2014.12.020
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  • 70. Zheng, X.; Xu, D.; Edgar, K.J., Cellulose Levulinate: a Protecting Group for Cellulose that can be Selectively Removed in the Presence of Other Ester Groups. Cellulose 2015, 22, 301-311. doi.org/10.1007/s10570-014-0508-8
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  • 69. Meng, X.; Matson, J.B.; Edgar, K.J. Olefin cross-metathesis, a mild, modular approach to functionalized cellulose esters. Polymer Chemistry, 2014, 5, 7021-7033. DOI: 10.1039/C4PY01102C
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  • 68. Liu, H.; Edgar, K.J., Synthesis and Characterization of Neutral and Anionic Cellulosic Amphiphiles. Carbohydrate Polymers, 2014, 113, 480-489. doi.org/10.1016/j.carbpol.2014.07.004
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  • 67. Zhang, R.; Kuang, J.; Zheng, X.; Edgar, K.J., Glycan ester deacylation by TBAOH or TBAF: regioselectivity vs. polysaccharide structure. Carbohydr. Polym. 2014, 113, 159-165. doi.org/10.1016/j.carbpol.2014.06.053
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  • 66. Pereira, J.M.; Edgar, K.J. Regioselective Synthesis of 6-Amino- and 6-Amido-6-deoxypullulans. Cellulose 2014, 21, 2379-2396. doi.org/10.1007/s10570-014-0259-6
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  • 65. Zheng, X.; Gandour, R.D.; Edgar, K.J. Remarkably Regioselective Deacylation of Cellulose Esters using Tetraalkylammonium Salts of the Strongly Basic Hydroxide Ion. Carbohydr. Polym., 2014, 111, 25-32. doi.org/10.1016/j.carbpol.2014.04.014
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  • 64. Marks, J.A.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. Pairwise Polymer Blends for Oral Drug Delivery. J. Pharm. Sci.2014, 103, 2871-2883. doi.org/10.1002/jps.23991
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  • 63. Zhang, R.; Edgar, K.J. Properties, Chemistry and Applications of the Bioactive Polysaccharide Curdlan.Biomacromolecules, 2014, 15, 1079-1096. doi.org/10.1021/bm500038g
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  • 62. Zhang, R.; Edgar, K.J. Synthesis of Curdlan Derivatives Regioselectively Modified at C-6: O-(N)-Acylated 6-Amino-6-Deoxycurdlan. Carbohydr. Polym. 2014, 105, 161-168. doi.org/10.1016/j.carbpol.2014.01.045
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  • 61. Meng, X.; Matson, J.B.; Edgar, K.J. Olefin Cross-Metathesis as a Source of Polysaccharide Derivatives: Cellulose ω-Carboxyalkanoates. Biomacromolecules 2014, 15, 177-187. doi.org/10.1021/mp400441d
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  • 60. Pereira, J.M.; Mejia-Ariza, R.; Ilevbare, G.A.; McGettigan, H.E.; Sriranganathan, N.; Taylor, L.S.; Davis, R.M.; Edgar, K.J. Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. Molecular Pharmaceutics, 2013, 10, 4640-4653.
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  • 59. Wegiel, L.A.; Edgar, K.J.; Taylor, L.S. Curcumin Amorphous Solid Dispersions: The Influence of Intra and Intermolecular Bonding on Physical Stability. Pharmaceutical Development and Technology, 2014, 19, 976-986. doi.org/10.3109/10837450.2013.846374
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  • 58. Pawar, S.N.; Edgar, K.J. Alginate Esters via Chemoselective Carboxyl Group Modification. Carbohydrate Polymers, 2013, 98, 1288-1296. doi.org/10.1016/j.carbpol.2013.08.014
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  • 57. Ilevbare, G.A.; Liu, H.; Pereira, J.M.; Edgar, K.J.; Taylor, L.S., Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics, 2013, 10, 3392-3403. doi.org/10.1021/mp400228x
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  • 56. Li, B.; Konecke, S.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. Curcumin Solubility and Chemical Stability are Enhanced by Solid Dispersion in Cellulose Ester Matrices Carbohydrate Polymers 2013, 98, 1108-1116. doi.org/10.1016/j.carbpol.2013.07.017
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  • 55. Zheng, X.; Gandour, R.D.; Edgar, K.J. TBAF-catalyzed Deacylation of Cellulose Esters: Reaction Scope and Influence of Reaction Parameters. Carbohydrate Polymers, 2013, 98, 692-698. doi.org/10.1016/j.carbpol.2013.06.010
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  • 54. Li, B.; Liu, H.; Amin, M.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose, 2013, 20, 2137-2149. doi.org/10.1007/s10570-013-9970-y
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  • 53. Ilevbare, G.; Liu, H.; Edgar, K.J.; Taylor, L.S., Impact of Polymers on Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Mol. Pharm. 2013, 10, 2381-2393. doi.org/10.1021/mp400029v
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  • 52. Zheng, X.; Gandour, R.D.; Edgar, K.J. Probing the mechanism of TBAF-catalyzed deacylation of cellulose esters.Biomacromolecules, 2013, 14, 1388-1394. doi.org/10.1021/bm400041w
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  • 51. Wegeil, L.A.; Mauer, L.; Edgar, K.J.; Taylor, L.S. Mid-Infrared Spectroscopy as a Polymer Selection Tool for Formulating Amorphous Solid Dispersions. J. Pharm. Pharmacol. 2014, 66, 244-255. doi.org/10.1111/jphp.12079
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