Kevin Edgar

Professor

Biomaterials and Bioprocessing; Director, ICTAS Bio-Based Materials Center; Ph.D.  (Duke)

Dr. Edgar's lab studies the synthesis, analysis, and structure-property-performance evaluation of polysaccharide derivatives. He has particular interest in the creation of novel drug-delivery systems based on polysaccharide derivatives, in order to address critical patient needs. He is interested in novel methods to control and utilize the nanostructure of polysaccharides and derivatives, in particular the regioselective substitution reactions of complex polysaccharides.

His research also addresses the broad and vital issue of identifying novel, high value biomaterials from biomass, and viable processes for their preparation. He is Associate Director for Research Initiatives in the Macromolecules and Interfaces Institute (MII), leads the Renewable Materials thrust and the Bio-based Materials Center of the Institute for Critical Technologies and Applied Science (ICTAS), and is a member of the Wood-Based Composites Center (WBC) and the Sustainable Engineered Materials Insitute (SEMI).

He is associate editor for the journals Cellulose and Carbohydrate Polymers. Dr. Edgar moved to Virginia Tech in 2007 from Eastman Chemical Company, where he was a Technology Fellow focusing on cellulose ester chemistry, drug delivery, and the creation of technology portfolios and organizations to support new business initiatives.

Area of Expertise

  • Creation of drug delivery systems to meet patient needs
  • Bioavailability enhancement
  • Synthesis of novel polysaccharide derivatives
  • Chemistry of cellulose and its derivatives
  • Polysaccharide chemistry
  • Structure-property-performance relationships of biomaterials and derivatives
  • Biomass conversion to high value biomaterials

Education

  • B.S. Bucknell University, 1975
  • Ph.D. Duke University, 1979

Polysaccharide Chemistry
SBIO/CHEM 5424 Spring 2012
Instructor: Kevin Edgar
Number of Students: 15

MACR 5015 Macromolecular Fundamentals

MACR 5015 Fall 2011
Instructor: Judy Riffle (KJE taught 4 lectures)
Number of Students: 18

Polymers in Medicine and Biology
GRAD 5134 Fall 2011
Instructor: Judy Riffle (KJE taught 2 lectures)
Number of Students: 25

Polysaccharide Chem. (WOOD/CHEM 5424)
WOOD/CHEM 5424 Spring 2011
Instructor: Kevin Edgar
Number of Students: 10

Macromolecular Fundamentals
MACR 5015 Fall 2010
Instructor: Judy Riffle, Kevin Edgar, others
Number of Students: 12

Polymers in Medicine and Biology
CHEM 5983 Fall 2010
Instructor: Judy Riffle
Number of Students: 30

Polysaccharide Chemistry
WOOD/CHEM 5424 Spring 2010
Instructor: Kevin J. Edgar
Number of Students: 18

Polymers in Medicine & Biology
MACR 5983 Fall 2009
Instructor: Judy Riffle, Kevin Edgar, others
Number of Students: 25

Polysaccharide Chemistry
WOOD 5424 Fall 2008
Instructor: Kevin J. Edgar
Number of Students: 13

Polysaccharide Chemistry
WOOD 5424 Fall 2007
Instructor: Kevin J. Edgar
Number of Students: 11

  • Liebert, T.F.; Heinze, T.J.; Edgar, K.J. 2010. Cellulose Solvents: For Analysis, Shaping and Chemical Modification. Editor, ACS Symposium Series 1033, 2010, ACS, Washington, DC.

  • Edgar, K.J.; Heinze, T.; Buchanan, C.M. 2009. Polysaccharide Materials: Performance by Design. Lead Editor, ACS Symposium Series 1017, ACS, Washington DC, 2009.
  • K.J. Edgar. 2009. Polysaccharide Chemistry: Frontiers and Challenges. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • C.M. Buchanan, N.L. Buchanan, K.J. Edgar, S. Klein, J.L. Little, M.G. Ramsey, K.M. Ruble, V.J. Wacher, M.F. Wempe. 2009. Building New Drug Delivery Systems: in vitro and in vivo studies of drug-hydroxybutenylcyclodextrin complexes. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • J.D. Posey-Dowty, M.C. Shelton, K.J. Edgar. 2009. Novel Cellulose Esters in Amorphous Matrix Drug Delivery. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design. K.J. Edgar, C.M. Buchanan, T. Heinze, eds.
  • K.J. Edgar. 2009. Synthetic Methods for Long-chain Esters of Cellulose. ACS Symposium Series, 2009, Cellulose Esters: Performance by Design, K.J. Edgar, C.M. Buchanan, T. Heinze, eds.

  • Edgar, Kevin J. 2007. Special Issue of Cellulose on Polysaccharides in Drug Delivery. Guest editorial in the journal Cellulose, Issue 1, Volume 14, 2007, pages 1-2.

Develop a Prototype Formulation for Drug Delivery
Investigator(s): L.S. Taylor, K.J. Edgar
Sponsor: NSF PFI: AIR
Amount: $68,000
August 15, 2013 - August 14, 2014

Collaborative Research: Polysaccharide Derivatives for Drug Delivery
Investigator(s): L.S. Taylor, K.J. Edgar
Sponsor: NSF Biomaterials
Amount: $325,000
January 15, 2013 - January 14, 2016

MRI: Acquisition of a dual size-exclusion chromatography- asymmetric flow field flow fractionation instrument
Investigator(s): J. McGrath, R.M. Davis, J.S. Riffle, S.R. Turner, K.J. Edgar
Sponsor: NSF
Amount: $255,265
August 1, 2011 - July 31, 2014

Aqueous GPC
Investigator(s): Edgar, K.J. (PI); Roman, M.; Renneckar, S.; Frazier, C.E. and 11 others
Sponsor: ICTAS
Amount: $136,000
March 1, 2011 - June 30, 2011

Regiospecific Synthesis of High-value Cellulose Esters and Ethers from Biomass
Investigator(s): Edgar, K.J. (PI); Buchanan, C.M.; Mischnick, P
Sponsor: USDA-NIFA
Amount: $816,049
February 1, 2011 - January 31, 2016

Amorphous Nanoparticles
Investigator(s): Edgar, K.J.; Davis, R.M
Sponsor: VT-CRI
Amount: $30,000
July 1, 2009 - June 30, 2010

SEMRR: Developing Sustainable Bioenergy Feedstocks and Cellulosic Composites
Investigator(s): Audrey Zink-Sharp, Chad Bolding, Carolyn Copenheaver, Kevin Edgar, Thomas R. Fox, Charles Frazier, Scott Renneckar, Maren Roman, and Shepard Zedaker
Sponsor: USDA NIFA Special Grant Program
Amount: $451,374.00
April 1, 2010 - March 31, 2012

Controlled Release of Phytochemicals
Investigator(s): Edgar, K.J.; Vinatzer, B
Sponsor: Fralin Institute
Amount: $15,000
June 1, 2010 - May 31, 2011

Enhanced Delivery of Phytochemicals by Nanodispersion in Polysaccharide Matrices
Investigator(s): K.J. Edgar, L.S. Taylor, L.J. Mauer
Sponsor: USDA
Amount: $405K
January 1, 2009 - December 31, 2011

Education Proposal: Bio-based Sustainable Materials as Resources for Tomorrow (BSMART)
Investigator(s): S. Renneckar, J. Barone, K. Edgar, A. Esker, J. Freeman, A. Morgan, and M. Roman
Sponsor: USDA CSREES
Amount: $500,000
December 1, 2009 - November 30, 2013

SEMRR: Creating Advanced Cellulosic Composites and Biobased Energy Feedstocks
Investigator(s): A.G. Zink-Sharp, K.J. Edgar, et al
Sponsor: USDA
Amount: $458K
September 1, 2009 - August 31, 2010

Cellulose Analysis
Investigator(s): Renneckar, S.H.; Edgar, K.J.; Zink-Sharp, A
Sponsor: US Army
Amount: $80,000
January 1, 2008 - January 31, 2009

SEMRR: Creating Advanced Cellulosic Composites and Biobased Energy Feedstocks
Investigator(s): Audrey Zink-Sharp, Kevin J. Edgar, Thomas Fox, Charles Frazier, Scott Renneckar, Maren Roman, and Shepard Zedaker
Sponsor: USDA CSREES Special Grants Program
Amount: $452,159
October 1, 2009 - September 31, 2011

Bio-Based Materials Center
Investigator(s): K.J. Edgar and 12 others
Sponsor: ICTAS
Amount: $110K
July 1, 2009 - June 30, 2010

Collaborative Research: Polysaccharide Derivatives for Enhanced Drug Delivery
Investigator(s): L. Taylor, K.J. Edgar
Sponsor: NSF
Amount: $404K
September 1, 2008 - August 31, 2011

Bio-based Materials Center at Virginia Tech
Investigator(s): Kevin J. Edgar, Foster Agblevor, Justin Barone, Alan R. Esker, Paul Gatenholm, Sean McGinnis, Abby Morgan, Scott Renneckar, Maren Roman, Zhiyou Wen, Y.-H. Percival Zhang
Sponsor: Virginia Tech Institute for Critical Technology and Applied Science
Amount: $205,303
January 1, 2008 - June 30, 2009

SEMRR:Innovative Forest Management Linked with High Performance, Wood-Based Composites
Investigator(s): Audrey Zink-Sharp, C. Copenheaver, K. Edgar, U. Egertsdotter, T. Fox, C. Frazier, S. Renneckar, M. Roman, and S. Zedaker
Sponsor: USDA CSREES McIntire-Stennis
Amount: $221,732
September 1, 2007 - August 31, 2008

 

  • Zhang, R.; Edgar, K.J. 2014. Synthesis of Curdlan Derivatives Regioselectively Modified at C-6: O-(N)-Acylated 6-Amino-6-Deoxycurdlan. Carbohydrate Polymers 105(-):161-168.
  • Meng, X.; Matson, J.B.; Edgar, K.J.. 2014. Olefin Cross-Metathesis as a Source of Polysaccharide Derivatives: Cellulose ω-Carboxyalkanoates. Biomacromolecules 15(-):177-187.
  • Zhang, R.; Edgar, K.J.. 2014. Properties, Chemistry and Applications of the Bioactive Polysaccharide Curdlan. Biomacromolecules 15(-):1079-1096.
  • Marks, J.A.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J.. 2014. Pairwise Polymer Blends for Oral Drug Delivery. Journal of Pharmaceutical Sciences DOI (10.1002/jps.23991):---.
  • Zheng, X.; Gandour, R.D.; Edgar, K.J. 2014. Remarkably Regioselective Deacylation of Cellulose Esters using Tetraalkylammonium Salts of the Strongly Basic Hydroxide Ion. Carbohydrate Polymers 111(-):25-32.
  • Pereira, J.M.; Edgar, K.J. 2014. Regioselective Synthesis of 6-Amino- and 6-Amido-6-deoxypullulans. Cellulose DOI(10.1007/s10570-014-0259-6):--.
  • Wegiel, L.A.; Edgar, K.J.; Taylor, L.S.. 2014. Curcumin Amorphous Solid Dispersions: The Influence of Intra and Intermolecular Bonding on Physical Stability. Pharmaceutical Development and Technology 19(-):976-986.
  • Liu, H.; Ilevbare, G.A.; Cherniawski, B.P.; Ritchie, E.T.; Taylor, L.S.; Edgar, K.J. 2014. Synthesis and structure-property evaluation of cellulose omega-carboxyesters for amorphous solid dispersions. Carbohydrate Polymers 100: 116-125.
  • Pereira, J.M.; Mejia-Ariza, R.; Ilevbare, G.A.; McGettigan, H.E.; Sriranganathan, N.; Taylor, L.S.; Davis, R.M.; Edgar, K.J.. 2013. Interplay of degradation, dissolution and stabilization of clarithromycin and its amorphous solid dispersions. Molecular Pharmaceutics 10(-):4640-4653.
  • Wegiel, L.A.; Mauer, L.J.; Edgar, K.J.; Taylor, L.S. 2013. Mid-infrared spectroscopy as a polymer selection tool for formulating amorphous solid dispersions. Journal of Pharmacy and Pharmacology -(-):na.
  • Li, B.; Konecke, S.; Harich, K.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. 2013. Solid dispersion of quercetin in cellulose derivative matrices influences both solubility and stability. Carbohydrate Polymers 92(-):2033-2040.
  • Li, B.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. 2013. Stability and solubility enhancement of ellagic acid in cellulose ester solid dispersions. Carbohydrate Polymers 92(-):1443-1450.
  • Zheng, X.; Gandour, R.D.; Edgar, K.J. 2013. TBAF-catalyzed Deacylation of Cellulose Esters: Reaction Scope and Influence of Reaction Parameters. Carbohydrate Polymers 98(-):692-698.
  • Li, B.; Konecke, S.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. 2013. Curcumin Solubility and Chemical Stability are Enhanced by Solid Dispersion in Cellulose Ester Matrices. Carbohydrate Polymers 98(-):1108-1116.
  • Ilevbare, G.A.; Liu, H.; Pereira, J.M.; Edgar, K.J.; Taylor, L.S. 2013. Influence of Additives on the Properties of Nanodroplets Formed in Highly Supersaturated Aqueous Solutions of Ritonavir. Molecular Pharmaceutics 10(-):3392-3403.
  • Pawar, S.N.; Edgar, K.J. 2013. Alginate Esters via Chemoselective Carboxyl Group Modification. Carbohydrate Polymers 98(-):1288-1296.
  • Pereira, J.; Mahoney, M.; Edgar, K.J. 2013. Synthesis of amphiphilic 6-carboxypullulan ethers. Carbohydrate Polymers 100: 65-73.
  • Zheng, X.; Gandour, R.D.; Edgar, K.J. 2013. Probing the Mechanism of TBAF-Catalyzed Deacylation of Cellulose Esters. Biomacromolecules 14(-):1388-1394.
  • Ilevbare, G.A.; Liu, H.; Edgar, K.J.; Taylor, L.S. 2013. Maintaining Supersaturation in Aqueous Drug Solutions: Impact of Different Polymers on Induction Times. Crystal Growth & Design 13(-):171-184.
  • Ilevbare, G.A.; Liu, H.; Edgar, K.J.; Taylor, L.S. 2013. Impact of Polymers on Crystal Growth Rate of Structurally Diverse Compounds from Aqueous Solution. Molecular Pharmaceutics 10(-):2381-2393.
  • Wegiel, L.A.; Mauer, L.J.; Edgar, K.J.; Taylor, L.S. 2013. Crystallization of Amorphous Solid Dispersions of Resveratrol during Preparation and Storage - Impact of Different Polymers. Journal of Pharmaceutical Sciences 102(1):171-184.
  • Li, B.; Liu, H.; Amin, M.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. 2013. Enhancement of Naringenin Solution Concentration by Solid Dispersion in Cellulose Derivative Matrices. Cellulose Fall, pp. na.
  • Li, B.; Wegiel, L.A.; Taylor, L.S.; Edgar, K.J. 2013. Stability and solution concentration enhancement of resveratrol by solid dispersion in cellulose derivative matrices. Cellulose 20(3):1249-1260.
  • Xu, D.; Voiges, K.; Elder, T.; Mischnick, P.; Edgar, K.J. 2012. Regioselective synthesis of cellulose ester homopolymers. Biomacromolecules 13( ):2195-2201.
  • Liu, H.; Kar, N.; Edgar, K.J. 2012. Direct synthesis of cellulose adipate derivatives using adipic anhydride. Cellulose , 19, 1279-1293.
  • Fox, S.C.; Edgar, K.J. 2012. Staudinger reduction chemistry of cellulose: synthesis of selectively O-acylated 6-amino-6-deoxycellulose. Biomacromolecules 13( ):992-1001.
  • Pawar, S.N.; Edgar, K.J. 2012. Alginate derivatization: a review of chemistry, properties and applications. Biomaterials 33( ):3279-3305.
  • Xu, D.; Edgar, K.J. 2012. TBAF and cellulose esters: unexpected deacylation with unexpected regioselectivity. Biomacromolecules 13( ):299-303.
  • Ilevbare, G.; Liu, H.; Edgar, K.J.; Taylor, L.S. 2012. Understanding polymer properties important for crystal growth inhibition - impact of chemically diverse polymers on solution crystal growth of ritonavir. Crystal Growth and Design 12, 3133-3143.
  • Ilevbare, G.A.; Liu, H.; Edgar, K.J.; Taylor, L.S. 2012. Effect of Binary Additive Combinations on Solution Crystal Growth of the Poorly Soluble Drug, Ritonavir. Crystal Growth & Design 12(-):6050-6060.
  • Ilevbare, G.A.; Liu, H.; Edgar, K.J.; Taylor, L.S. 2012. Inhibition of solution crystal growth of ritonavir by cellulose polymers - factors influencing polymer effectiveness. CrystEngComm 14(-):6503-6514.
  • Fox, S.C.; Edgar, K.J. 2011. Synthesis of regioselectively brominated cellulose esters and 6-deoxy-6-cyanocellulose esters. Cellulose 18( ):1305-1314.
  • Kar, N.; Liu, H.; Edgar, K.J. 2011. Synthesis of Cellulose Adipate Derivatives. Biomacromolecules 12(na):1106-1115.
  • Xu, D.; Li, B.; Tate, C.; Edgar, K.J. 2011. Studies on regioselective acylation of cellulose with bulky acid chlorides. Cellulose 18(2):405-419.
  • Fox, S.C.; Li, B.; Xu, D.; Edgar, K.J. 2011. Regioselective Esterification and Etherification of Cellulose - A Review. Biomacromolecules 2011, 12, 1956-1972.
  • Pawar, S.N.; Edgar, K.J. 2011. Chemical modification of alginates in organic solvent systems. Biomacromolecules 12( ):4095-4103.
  • Collnot, E.M.; Baldes, C.; Schaefer, U.; Edgar, K.J.; Wempe, M.F.; Lehr, C.-M. 2010. Vitamin E TPGS P-Glycoprotein Inhibition Mechanism: Influence on Conformational Flexibility, Intracellular ATP Levels, and Role of Time and Site of Access. Molecular Pharmaceutics 7(3):.
  • Klein, S.; Wempe, M.F.; Zoeller, T.; Buchanan, N.L.; Lambert, J.L.; Ramsey, M.G.; Edgar, K.J.; Buchanan, C.M. 2009. Improving glyburide solubility and dissolution by complexation with hydroxybutenyl-beta-cyclodextrin. J. Pharm. Pharmacol 61(2009):23-30.
  • Wempe, M.F.; Wright, C.; Little, J.L.; Lightner, J.W.; Large, S.E.; Caflisch, G.B.; Buchanan, C.M.; Rice, P.J.; Wacher, V.J.; Ruble, K.M.; Edgar, K.J. 2009. Inhibiting efflux with novel non-ionic surfactants: Rational design based on vitamin E TPGS. Int. J. Pharm 370(2009):93-102.
  • Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Little, J.L.; Ramsey, M.G.; Ruble, K.M.; Wacher, V.J.; Wempe, M.F. 2008. Pharmacokinetics of Saquinavir after Intravenous and Oral Dosing of Saquinavir-Hydroxybutenyl-beta-cyclodextrin Formulations. Biomacromolecules 9(1):305-313.
  • Wempe, M.F.; Wacher, V.J.; Ruble, K.M.; Ramsey, M.G.; Edgar, K.J.; Buchanan, N.L.; Buchanan, C.M. 2008. Pharmacokinetics of Raloxifene in Male Wistar-Hannover Rats: Influence of Complexation with Hydroxybutenyl-beta-cyclodextrin. Int. J. Pharm 346(1-2):25-37.
  • Collnot, E.-M.; Baldes, C.; Wempe, M.F.; Kappl, R.; Hattermann, J.; Hyatt, J.A.; Edgar, K.J.; Schaefer, U.F.; Lehr, C.-M.. 2007. Mechanism of inhibition of P-glycoprotein mediated efflux by Vitamin E TPGS: Influence on ATPase activity and membrane fluidity. Molecular Pharmaceutics 4(3):465-474.
  • Wempe, M.F.; Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Hanley, G.A.; Ramsey, M.G.; Skotty, J.S. Rice, P.J.. 2007. Pharmacokinetics of Letrozole in Male and Female Rats: Influence of complexation with Hydroxybutenyl-beta-cyclodextrin. J. Pharm. Pharmacol 59(6):795-802.
  • Posey-Dowty, J.D.; Watterson, T.L.; Wilson, A.K.; Edgar, K.J.; Shelton, M.C.; Lingerfelt, L.R. Jr. 2007. Zero-Order Release Formulations using a Novel Cellulose Ester. Cellulose 14(1):73-83.
  • Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Ramsey, M.G. 2007. Solubility and Dissolution Studies of Antifungal Drug:Hydroxybutenyl-beta-Cyclodextrin Complexes. Cellulose 14(1):35-47.
  • Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Little, J.L.; Malcolm, M.O.; Ruble, K.M.; Wacher, V.J.; Wempe, M.F. 2007. Pharmacokinetics of Tamoxifen after Intravenous and Oral Dosing of Tamoxifen-hydroxybutenyl-beta-cyclodextrin Formulations. J. Pharm. Sci 96(3):644-660.
  • Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Klein, S.; Little, J.L.; Ramsey, M.G.; Ruble, K.M.; Wacher, V.J.; Wempe, M.F. 2007. Pharmacokinetics of Itraconazole after Intravenous and Oral Dosing of Itraconazole - Cyclodextrin Formulations. J. Pharm. Sci 2007(11):3100-3116.
  • K.J. Edgar. 2007. Cellulose Esters in Drug Delivery. Cellulose 14(1):49-64.
  • Buchanan, C.M.; Buchanan, N.L.; Edgar, K.J.; Lambert, J.L.; Posey-Dowty, J.D.; Ramsey, M.G.; Wempe, M.F. 2006. Solubilization and Dissolution of Tamoxifen-hydroxybutenyl Cyclodextrin Complexes. J. Pharm. Sci 95(10):2246-2255.
  • Collnot, E.M.; Baldes, C.; Wempe, M.F.; Hyatt, J.; Navarro, L.; Edgar, K.J.; Schaefer, U.F.; Lehr, C.M. 2006. Influence of Vitamin E TPGS Poly(ethylene glycol) Chain Length on Apical Efflux Transporters in Caco-2 Cell Monolayers. J. Controlled Release 111(1):35-40.
  • Buchanan, Charles M., Norma L. Buchanan, Kevin J. Edgar, James L. Little, Michael O. Malcolm, Karen M. Ruble, Vincent J. Wacher and Michael F. Wempe. 2006. Pharmacokinetics of Tamoxifen after Intravenous and Oral Dosing of Tamoxifen-Hydroxybutenyl-β-Cyclodextrin. Journal of Pharmaceutical Sciences 96(3):644-660

 

Headshot of Kevin J. Edgar
Kevin J. Edgar
  • (540) 231-0674
  • kjedgar@vt.edu
  • Sustainable Biomaterials
    230 Cheatham Hall (0323)
    Blacksburg, VA
    24061